Gilles Simon fended off Australian ace Bernard Tomic in a rain affected Centre Court contest 7-6 6-3.
The French #2 seed took the pace off the drives from the confident 20-year-old hot-shot, but made heavy weather of progressing to the semi-final.
The tiebreak was fiercely contested, Simon edged ahead 10-8 and made a formidable start to the second set.
But light rain suspended the tie at 4-1 with Tomic set to serve. The return to court was brief, lasting 10 minutes, with Simon sealing success in their first ever encounter but being pegged back from a 5-1 lead.
Tomic narrowly missed out on earning his first semi-final berth since racing to his inaugural ATP Tour crown at Sydney in January.
John, his father and coach, would have been delighted by the start from the world #64 until he fluffed two set points on Simon’s serve at 5-4.
The French ace faces Italian Andreas Seppi, who has roared into his third successive Eastbourne semi-final and won the 2011 Aegon International as well as finished runner-up last year.