Agnieszka Radwanska, competing in her 10th successive Eastbourne tournament, was gifted a 3rd Round face-off against Eugenie Bouchard.
The 2008 Aegon International champion was leading German-born Croatian Mirjana Lucic-Baroni when the 32-year-old retired.
And unfortunately for veteran Lucic-Baroni, who has never won a WTA Tour title, she bowed out trailing 6-4 2-1 with a gastrointestinal illness.
Her aggressive baseline style gave the Pole concerns in the opening set, but Lucic-Baroni – who slipped up during Qualifying at last week’s Aegon Classic in Birmingham – fell behind.
She was troubled by her illness at the start of the second set, but could go on no longer because of the pain.
“We are all hoping that she gets better soon. It was still a tough match because she was playing really good tennis. Overall I’m happy that I could get some time on the grass.”
The Pole, top seed at both Nottingham’s Aegon Open and Birmingham’s Aegon Classic, made swift exits at the English grass events was aiming to get her game into gear.
Yet Radwanska, last year’s runner-up at Devonshire Park to Swiss teenager Belinda Bencic, stuttered throughout and lacked her usual panache.
Next up for the world #3 is a showdown against charismatic Canadian Eugenie Bouchard, who has registered rare back-to-back wins on Tour.
In the battle of former Wimbledon finalists, unseeded Bouchard is in emphatic form and on a crest of a wave after signing with a new agent and destroying all those on the opposite side of the net.