Petra Kvitova, the Wimbledon winner, is due to play her first grass court match since being crowned champion at SW19 when she opens up Centre Court proceedings against Russian Ekaterina Makarova.
But the 22-year-old Czech Republic ace faces a stern task as Makarova won the 2010 Eastbourne title.
Caroline Wozniacki, another former Devonshire Park champion, has a tricky task in her 1st Round clash against American Christina McHale second on Centre Court.
The great Dane has a new bite about since installing a coach to guide her back to her not so distant former glories. The ex-world #1 will be aiming to emulate her 2009 run to the title on her first return to Devonshire Park since that triumph.
The all-American clash between the big servers is a mouth-watering tie, third on Centre Centre. Andy Roddick, a three-time Wimbledon runner-up, and Sam Querrey are playing well below their usual standard with a run at the Aegon International needed by both to boost much-needed confidence.
Agnieszka Radwanska, the 2008 Eastbourne winner and top seed, has a battle against Bulgarian beauty Tsvetana Pironkova in the second match on Court 1.
Marion Bartoli will begin the defence of her title by bringing her unorthodox French flair against Romanian Sorana Cirstea for the third match on Court 1.